Thursday, April 9, 2020

A Rear View on Pandemics


Coronavirus: Trump says coronavirus crisis may last all summer ...

Prophet or Pretender?

The text below is something I wrote in 1998/99 as part of a treatment on futurism in Health  Care.  Be cautious how you handle this.  It can give you whiplash:

In Canada,  the provinces are locked in danse macabre with the federal government over their respective shares of national health care expenditures.  Managed care doesn’t have the same profile as privately-run HMOs do in the U.S., but provincial health programs exhibit many of the same characteristics.  Gaps have appeared in medicare coverage as provinces have eliminated overlap and  duplication and, in some cases reduced expenditures.

 Until the 1990s, equality of access to care was assumed by most Canadians to be another of their birthrights.  However, as public health has become a commodity as well as a medical service, there are widespread fears that a two-tier system -- one in which people with the most means will get the best care -- will one day be the norm.   The concept of “two-tier” health care has become the dividing line between those who consider equal access to high-quality medical treatment to be a sacred trust of national governance and those who fear that soaring medical costs could sink the Canadian federation almost as surely as the traditional ideology of Quebec separatism.           

At mid-century, few people imagined -- the lifestyles editor of The Futurist among them -- that along the way, the economics of distribution would create bottlenecks that may be more difficult to overcome, in the long run, than the diseases themselves.  As it has turned out in the Nineties, the cost of health care has become nearly as problematic as disease itself.

Medical technology has demonstrated repeatedly that it can deliver great advances in the treatment of many illnesses that have plagued humanity for at least as long as there have been records of public health.   Our faith in the promise of science has proved to be well-placed as each age-old malady has succombed to the accumulated knowledge and skill of medical research.  By the 1970s, it was common wisdom to declare that the war of bugs versus drugs had been won decisively.  Yet new challenges have emerged with each success.  New diseases, like AIDS, have probably crossed over from exotic jungle creatures to attack the human organism as greater numbers of people have ventured into the dark recesses of the planet.  Ebola, a ghastly hemorrhagic fever that causes the body to ooze streams of blood, was first identified in western Sudan and Zaire in 1976.  It had likely existed for eons in some forest rodent or bat species.  And now old diseases like influenza and common infections, once thought to have been eradicated, are threatening to invade us.   Technology is surrendering its power to newly resistant strains of micro-organisms that have co-existed with us peaceably for generations.

Medical researchers understand that our weakness for a sure thing is almost certain to be our downfall.  The question is not whether this will come about, but when it will occur.   We have become so accustomed to a life without the risk of the age-old infections that our very aversion to any such risk will be our undoing.  We insist so firmly on narrowing the probability of a foreshortened future that our very insistence will be the death of us.  Our demands for antibiotic insurance against every discomfort have become so strong that doctors have given in to the pressure.  According to one U.S. study, between 20 and 50 per cent of the 145-million prescriptions given each year to outpatients are unnecessary.[1]   Between 25 and 45 per cent of the 190-million antibiotic doses administered in the hospital each year are equally superfluous, the study found.  Antibiotics are often taken for illnesses that they are not even designed to fight, like colds or flu, that are caused by viruses.  

Bacteria are among the oldest organisms on the planet.  What they do best of all is to survive.  They were doing this according to Darwinian principles eons before the great 19th century botanist enunciated his Theory of Evolution.  The emergence of resistant bacteria was inevitable.  But nobody predicted how quickly it would happen.  It has taken these organisms with a genius for adaptation less than half a century to overcome the most potent concoctions that mankind could devise.  Bacteria now exist for which there is no antibiotic antidote.  Some are resistant not to one drug, but to many. 

North America has become addicted to the antibiotic cocktail.  What happens next may turn out to be the nightmare of all hangovers. The next pandemic will almost certainly be the result of resistance to the cure.  The growing list of dangerously infectious, drug-resistant microbes is comprised of common household bugs that cause everyday maladies like sore throats, ear infections and influenza.  Headline writers have enthusiastically taken to calling them the “Superbugs”.  As the headlines tell the story, it’s as though each microbe has assumed heroic dimensions of virulence.  It is an imperfect caricature.  The real story is far more banal and, because of that, infinitely more menacing.  Organisms that live on the skin and in the nostrils of otherwise healthy people are threatening to overcome all the miracle drugs now known to medical research.  Their supremacy would be a terrible thing to behold.  More unsettling than this apocalyptic vision, however, is the consensus among epidemiologists.  They are nearly unanimous about the high probability of the threat.

Between 20 and 30 million people died world-wide in the Spanish Flu epidemic of 1918-1919.  The one-month death toll was more than 200,000 North Americans from a population at the time of less than 60-million. Epidemiologists agree that athere is a good probability of a pandemic of similar proportions  within the first five years of the new century, based on the calculation that major epidemics occur three or four times a century.  Thirty years have elapsed since the last one.  The longest span without one in the 20th Century was 39 years.  How prepared is the medical estabishment?  “I don’t think anyone could ever be ready for something like that,” says Health Canada’s chief epidemiologist. “How can you prepare?” [2]     

Ironically, the man who created the first miracle drug foresaw where all this was headed.  Penicillin was introduced in 1943.   Just two years later Alexander Fleming, the drug’s discoverer, warned in an interview that misuse of penicillin would cause bacteria to mutate into new strains.  These new organisms would exist solely to resist the new drug.   As things have turned out, the evolution of bacteria into increasingly virulent strains has been occurring faster than the ability to produce new medicines.   In part that is because drug manufacturers all but abandoned the search for new antibiotics in the early 1980s, believing that bacterial infections were under control once and for all. 

If medical science is about to lose its grip on infectious diseases, it  couldn happen at a worse time. Hospital cutbacks mean there is little capacity in the health system to care for  the victims of any  new pandemic.  Most likely, if one should occur, the corridors would be choked with [seething] masses, like some medieval mortuary.  




            [1] Superbugs, New York Times Magazine, August 2, 1998, p. 42.
            [2] Interview January 11, 1999 with Dr. John Spika (957-4243)